The crash happened shortly before 4pm, when a car and a truck collided on Tomingley Road, about 30km south of Narromine. Officers from the Orana Local Area Command attended and launched an investigation. 

The driver of the car, a 50-year-old woman, died at the scene. 

The truck driver, a 55-year-old man, was treated at the scene by NSW Ambulance Paramedics, before being taken to Dubbo Base Hospital for mandatory drug and alcohol tests. 

Traffic diversions were in place for the remainder of the evening and well into the night. 

Police are preparing a report for the information of the Coroner following the death of the woman. 

The police have surmised fatigue may have been a factor, but this is pending further investigations and a report for the Coroner.