If you didn't stumble onto season one of 9GO!'s Metro Sexual you might want to binge it on 9 Now to catch up to this off-the-wall mockumentary.

The Metropolitan Sexual Health Clinic is a breeding ground (pardon the pun) for left field humour centred on genitalia and all the diseases that spring up thereon.

Co-creator, producer and star Riley Nottingham is the effervescent Dr Langdon Marsh.

"I'm a fairly optimistic kind of person, so you could say there is a lot of Langdon in me," Nottingham says.

Alongside Langdon is the sardonic, seemingly aloof, Doctor Steph Huddleston (Geraldine Hickey).

"We approached Geraldine when we were developing it [the show]

"Geraldine is absolutely bloody fantastic. We are so lucky to have her.

"Urvi (Majumdar, who plays the world's worst receptionist Gwen) was recommended by Gez [Geraldine].

"And we worked with casting agency Chicken and Chips.

"Ryan [Shelton, who plays Dr Huddleston's clueless bikie cousin Greg] and Shabana [Azeez, who plays superior medical student Yasmin Dagher] - we worked with them a bit in season one and wanted to expand their roles.

"Some friends are in the mix, but every single person beat out hundreds of others [in auditions].

"Some of the guests for season two we have been massive fans of, and were so happy to be able to get to work with them."

Nottingham gives much of the creative credit to his Humdrum Comedy colleagues Henry Boffin and Nicholas Kraak.

"We wanted to develop something more meaningful after we did the [14-part] series Hitstroke FM set in Australia's worst radio station.

"Sexual health is an awkward subject that people of any age can relate to. Half a decade later, we came up with Metro Sexual."

"They're [Henry and Nick] geniuses and so good at working with the cast. They have seen how it worked in season one and have written to the characters in season two. We've even got some of season three underway. It definitely doesn't suck to be us."

Nottingham says the show's audience is quite broad, and not just in Australia. The first season screened in Canada, New Zealand, the United Kingdom, Ireland, and the United States.

"We get messages from fans of all ages. The appeal is pretty broad because most people have some experience with intimacy, and relationships."

One of the difficulties of writing and acting in a medical show is the getting the tongue twisting symptom and pharmaceutical names correct.

"One of my older brothers is an anaesthetist so I would ask him, he was a godsend for me. Plus we had Dr Ryan Williams, a sexual health physician in Queensland, working with us and one of our in-kind sponsors would also help."

This season's episodes are slightly longer and Nottingham is happy they are able to delve a little deeper into sexual health issues.

"We want people to be empowered to have a conversation with their doctor.

"It can be a taboo issue, so when it came to season two, we wondered should we include the short public service style messages at the end.

"But there is no negative for us. We can give a bit of education about sexual health in a good way.

Could some people see these aphorisms as trivialising the subject.

"With comedy in general you are able to approach something with humour as a way of getting through to people. We tried hard not make too light of issues in the show," Nottingham says.

"I like to think it's the kind of show I could watch with my parents."